Modulating P65 and TRAF6 Promotes Microglial Immunosuppression by Chronic Morphine-Induced MicroRNA-124
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Cocaine-mediated promoter DNA methylation of microRNA-124 promotes microglial activation through TLR4 signaling
Neuroinflammation plays a critical role in the development of reward-related behavior in cocaine self-administration rodents. Cocaine, one of most commonly abused drugs, has been shown to activate microglia both in vitro and in vivo. Detailed molecular mechanisms underlying cocaine-mediated microglial activation remain poorly understood. MicroRNAs (miRs), belonging to a class of small non-codin...
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